Hyperinsulinemia Might cause Diabetes
It is reported that average time from blood glucose increasing to appearance of clinical symptoms may be as long as seven years. Clinically, there are the following development procedures: the first step is normal fasting blood glucose, but with abnormal blood glucose tolerance, it means that blood glucose two hours after a meal is a little higher, but no more than 7.8mmol/L. The second step is increasing of fasting blood glucose but is not higher than 7mmol/L, blood glucose two hours after a meal is ≥7.8mmol/Lbut<11.1mmol/L. If both of these two steps should arouse you attention, it will develop into the third step, fasting blood glucose is increasing and is more than 7mmol/L, blood glucose two hours after a meal is ≥11.1mmol/L, and it can be diagnosed as Diabetes. Within this period, if you didn’t do any examination, and there is no symptom. As the illness process, it will develop into the fourth step. Clinical symptoms of ‘three highs, one low’ will show up, without being diagnosed by doctor, they could know that you have been attacked by Diabetes. In this condition, patients with Diabetes know they should use some drugs to control their disease.
From the above we can see that it is very important to prevent the first and the second step. Especially in the development course of type ⅡDiabetes, two important basic links and characteristics might appear, they are insulin resistance and defect of insulin secretion. Insulin secretion is a kind of phenomenon which biological reaction of organisms to certain amount of insulin is lower than normal level. Patients in this period, glucose absorption ability of serum insulin is decreasing, at the same time generation of liver glucose is increasing. In order to solve this problem, compensation of insulin secretion increases, thus maintaining blood glucose on a foundation level. As time went by, clinical Hyperinsulinemia appears. Defect of insulin secretion is another kind of variation, insulin secretion induced by continuous intravenous drip of glucose is presenting twin peaks. Earlier secretion peak appears in the beginning ten minutes, and then it decrease rapidly. If maintaining intravenous drip continuously, the second peak will appear after about 90minutes. Secretion of insulin continuously increases, it will hold for some time when it reach summit.
Defect of insulin secretion, early secretion is lost or deficient, and the second peak of insulin is delayed. At the beginning, increasing insulin induced by glucose after meal can return blood glucose to normal. With the development of functional deficiency of pancreas beta cells, it will develop into high level of fasting blood glucose. Stimulation of lasting high blood glucose can promote development of Hyperinsulinemia, thus reducing insulin receptors, lowering insulin affinity, aggravating insulin resistance.
While clinical doctors neglect Hyperinsulinemia when they are diagnosing a patient disease, they neither detect the combining ability of insulin receptors, nor examine if there is insulin resistance, thus missing the best chance of preventing development of Diabetes.
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