Do You Know Causes and Pathogenesis of Diabetes Type 1

Autoimmune response

In Diabetes Type 1 the beta cells in the pancreas that make insulin are destroyed gradually, causing a severe lack of insulin. This is thought to be the result of the body attacking and destroying its own cells in the pancreas. Though the first start of this cascade of immune events is unknown, it is suggested by evidence that both a genetic predisposition and environmental factors, such as a viral infection, are involved.

Hereditary factor

According to researchers, at least eighteen genetic locations are related to Diabetes Type 1. The locations are labeled IDDM 1 to IDDM 18. The genes of IDDM1 region can affect the immune response, but other genetic components of the disease are still being identified by advanced research. It is found that most people with Diabetes Type 1 do not have a family history. Children usually tends more likely to inherit the disease from a father than a mother with this disease.


Infection with a specific virus or bacteria may trigger Diabetes Type 1. Coxsackieviruses are the most likely factors to cause the disease. Other factors also include mumps and congenital rubella.

In all, Diabetes Type 1 can be caused by factors above. As a common disease of children, it can occur at any age but tends to develop in childhood. Besides effective treatment, you can successfully manage this disease with medication, dietary modifications and exercise. You can contact us online for more information if you need any help.

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