Pathogenesis of Diabetic Nephropathy ( Diabetic Kidney Disease )
1. Glomerular hemodynamics change
The high blood sugar and glycated protein increase the GFR and inner pressure of glomerular which can damage the glomerular capillary endothelium cells leading to the enhanced permeability of filtration membrane, as a result of which, more macromolecule substance will pass into the mesangial area stimulating the proliferation of mesangial cells and promoting glomerulosclerosis.
2.Biochemical metabolic disorder
Polyalcohol activation and lipid metabolic disorder are the factors. Glucose can be transformed into fatty acid which can combine with glyceroester to form TG, which elevate the TG, Tch and LDL in blood. Abnormal lipid metabolic disorder can damage kidneys and promot the onset of glomerularsclerosis.
3. Blood rheology change.
The barriers of blood rheology in diabetes patients are characterized by coherence, hyperviscous and low erythrocyte deformability which lead to blood stasis and thrombosis in the capillary vessels.
4. High blood pressure influence the attack of diabetic nephropathy
Diabetes patients accompanied with high blood pressure can have increased glomerular inner pressure due to renal artery sclerosis and regulatory barrier of renal blood vessels.
The above is a brief introduction of pathogenesis of diabetic nephropathy. If you have more questions about diabetic nephropathy, you can consult the experts online about your concerns. We are glad to help you!
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