The Causes of Diabetic Nephropathy
What are the causes of diabetic nephropathy?
1. The change of glomerular hemodynamics.
GFR(glomerular filtration rate) and pressure of glomeruli increase due to the high blood glucose in diabetes people damage the cells in the glomearuli and increase the permeability of filtration membrane. Consequently, glomerulosclerosis occurs. High blood glucose increases the renal blood flow, leading to a high GFR. Meanwhile, high blood glucose also increases the renin and gnigotensin II, leading to an increased permeability of glomerular filtration membrance so that proteinuria occurs.
High blood pressure
High blood pressure in diabetes can promote the form of glomerulosclerosis due to the disorder of regulating blood pressure. High blood pressure is a dangerous factor which affects the kidneys. In turns, kidneys disease can cause high blood pressure so that high blood pressure and kidney disease are always hand by hand. Controlling high blood pressure is the key to prevent kidney disease in diabetes people.
Hemodynamic change leads to blood stream stasis and thrombus in blood vessels which is caused by many factors.
Diabetic nephropathy is due to the kidney damage caused by the high blood glucose. The goal of diabetic nephropathy treatment is to restore the kidneys and protect the refractory renal function. Learn more Stem Cells Treat Diabetic Nephropathy to restore your kidneys.
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