Pathogenesis of Diabetic Nephropathy

Most of Diabetic Nephropathy patients have suffered from Diabetes for more than 10 years. With proteinuria as the earliest symptom, Pathogenesis of Diabetic Nephropathy is very complex and has not been completely clarified. Research materials show that the pathogenesis includes factors as follows:

Renal Hemodynamics Abnormality

It takes crucial effect in the development of Diabetic Nephropathy and even acts as the initial factor.

(1) When high blood glucose presents, there appears state of hypertransfusion and high filtration within the glomeruli.

Increasing pressure of cross capillary wall expands mesangial cells. Foot process of epithelial cells fuse and produce compact drops. Glomerulus epithelial cells drop off the basement membrane.

(2) Glomerulus basement membrane type Ⅳcollagen makes KNA increase, basement membrane thicker, and finally form diffusive and focal segmental pathological changes of basement membrane which leads to glomerulosclerosis.

(3) With increased pressure, protein filtration increases,and also some protein deposit in the mesangial region and glomerulus basement membrane to promote hyperplasia of stroma. Vicious cycle forms and will cause nodular and diffuse glomerulosclerosis.

High Blood Glucose

Diabetic Nephropathy has close relation with high blood glucose. It will accelerate the presence and development of Diabetic Nephropathy if blood glucose isn’t controlled well. On the contrary, good control will delay the development. High blood glucose and the increasing of end product of glycosylation can cause mesangial cells to proliferate, extracellular matrix to increase, mesangial area to expand, and Glomerulus basement membrane to thicken.

Genetic Factor

Most Diabetics will not present renal pathological changes at last, but some patients with long-term good control of blood glucose may suffer from Diabetic Nephropathy. Family cluster will occur. Among some Diabetics who have high blood pressure family history, the morbidity of Diabetic Nephropathy is obviously higher than those who have no family history. In addition, the morbidity differs among different races. All these indicate that presence of Diabetic Nephropathy has relation with Genetic Factor.

High Blood Pressure

It has no directly relation with presence of Diabetic Nephropathy. However, primary high blood pressure or when entering into the microalbuminuria period, elevated blood pressure will quicken development of Diabetic Nephropathy, deteriorates renal function and aggravate excretion of urinary albumin.

As one of the most severe complication of Diabetes, Diabetic Nephropathy brings much trouble to us. Timely treatment is definitely necessary. If you want to know more about Diabetic Nephropathy treatment, please consult our online experts.

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