Diagnostic Bases of Diabetic Nephropathy
The diagnostic bases of Diabetic Nephropathy are:
1. Renal Failure
Renal Failure is characterized by decreasing glomerular filtration rate (GFR). GFR is used to describe the flow rate of fluid that filtrated through the kidney. As we all know, one of the main functions of the kidney is to filtrate blood. Decreasing in GFR indicates the dysfunction of the kidney.
Once the Diabetic Nephropathy occurred, the course would be progressive. Eventually, the disease will progress to End-Stage Renal Disease or Azotemia.
Hypertension usually seen on patients with Diabetic Nephropathy. Most patients with Diabetic Nephropathy are also suffering from Hypertension. What is worse, Hypertension can aggravate the development of Diabetic Nephropathy.
Patients with Azotemia may suffer from mild to moderate Anemia and iron preparation can't alleviate this condition. Anemia can be caused by many factors, such as Dyserythropoiesis, long-term protein restriction or Azotemia.
Edema usually do not occur during the early stage of Diabetic Nephropathy while some may have mild edema before the fall of plasma protein level. Edema often occurs when the 24-h urine total protein level is beyond 3 grams. Obviously systemic edema may occur on patients with rapid development of Diabetic Nephropathy.
Microalbuminuria may present in urine that due to glomerular hyperfiltration or changes of the electric charges on the filter membrane. The presence of microalbuminuria occurs in this stage is called selective proteinuria. This condition may last for several years without increasing globulin. Along with the enlargment of the further destroying of the glomerular basement membrane, nonselective proteinuria may occur and keep on progressing to persistent severe proteinuria. Proteinuria over 3 grams per day is a sign of unfavourable prognosis. Most severe persistent proteinuria may develop continually until Nephrotic Syndrome occur.
After reading this article, did you get a better view of diagnostic bases of Diabetic Nephropathy? These diagnostic bases are very important in diagnosing Diabetic Nephropathy. If you still have any problem about it you can contact our experts on line.
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