Early Signs of Renal Failure in Diabetics
1. Increasing protein output in urine
Proteinuria is the typical symptom of diabetic kidney disease, which is a result of glomerular damage caused by high blood glucose.
Clinically, kidney damage caused by diabetes develops through five stages, while the first two stages show no symptoms and are characterized by changes in kidneys, microalbuminuria(30～300mg/24h) appears in the third stage. With kidney function declining, more and more proteins will be leaked into urine. Patients suffering from increasing protein output in urine may develop fast into renal failure stage.
2. Severe swelling
At initial time, swelling will present in the eyelid or appear with slight extent in the legs. When the disease enters chronic renal failure, swelling may well present in main parts of the body such as face, both legs or even ascites, pulmonary edema or hydropericardium.
3. Discomforts in the body
An important index for kidney damage is creatinine, which appears when kidney functions have decreased for 50 percent. Accumulated wastes and toxins can lead to overall discomforts, such as poor appetite, nausea, poor sleeping quantity, itching and fatigue.
4. Frequently urine at night
Increased urine at night is caused by damages of kidney concentration functions.
The severely impaired kidneys can not produce enough EPO so that anemia can appear. Patients with anemia may often experience cold and fatigue.
There can also be many other symptoms when kidneys are severely impaired. There can be complications in other organs due to intrusion of high blood glucose to microvascular systems, which can be life-threatening. So diabetics should keep alert and take immediate treatment so as to avoid further deteriorating condition.
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