Case:Treating Diabetic Nephrophathy(DN) with Micro-Chinese Medicine Osmotherapy and Stem Cell Transplant

Patient: Wang Ran, female, 59 years old

Main complaints

Diabetes for ten years, polydipsia and polyphagia accompaied by weight loss for ten years, diagnosis of Diabetic Nephropathy one year ago, progressvie swelling in the legs for one year, aggravated swelling in January. She was admitted to Shijiazhuang Kideny Disease Hospital on 26th March, 2011.

Main admission examinations

Blood pressure 180/90 Hg; finger-concavity edema in the legs; urinalysis: proteinuria+++, 24-hour urinary protein 4.35 g/L; blood routine examination: WBC 3.7×10/L,RBC 3.11×10/L,HGB90g/L; cold extremities, weakened artery pulse on bilateral dorsalis pedis.

Admission diagnosis

Type 2 Diabetes, Diabetic Nephropathy Stage IV, Diabetic peripheral neuropathy, hypertension 2( high-risk group).

Treatment process with Micro-Chinese Medicine Osmotherapy and Stem Cell Transplant

Conventional antyhypertensive medicines; daily insulin dose 34U (18U in the morning and 16U in the evening); Micro-Chinese Medicine Osmotherapy two times a day; Stem Cell Transplant with cord blood stem cells for one time on 7 April, 2011.

After treatment

17 days after admission, 24-hour urinary protein 2.69g/L;

After leaving hospital, continue to examinaine blood sugar level and reduce insulin intake gradually;

70 days after leaving hospital: 24-hour urinary protein 1.60/g in reexmination; daliy insulin intake reduced to 14U, fasting blood glucose 6mmol/L and blood sugar two hours after meals 9 mmol/L; blood pressure controlled at 100-110/80-85 Hg without taking antipypertensive medicines;swelling disappears; stable illness condition.

Expert's comment

Diabetic Nephropathy often combines faliure in multiple organs. In this case, the patient has a history of Diabetes for more than ten years, long-term poor blood pressure controlling is the main cause for Diabetic Nephropathy.

Through years of clinical practice, it has been proved that combination of Stem Cell Transplant and Micro-Chinese Medicine Osmotherapy can repair insulin release function, improve insulin resistance and repair damaged kidney function:

Firstly, Micro-Chinese Medicine Osmotherapy can decrease immune reactionm and blood viscosity, and improve renal ischemia with its functions of expanding blood vessels, anti-flammation and anti-coagulation. Moreover, with the blocking, repairing and reconstructing process, it offers a good enviornment for Stem Cell Transplant to take on effect.

Further, Stem Cell Transplant can increase endogeneous islet cell secretion due to the multiple-differentiation and self-replication poteintials of stem cells. More exactly, stem cells can crack and repair damaged islet cells, promote the regenaration of endogeneous islet cells. Therefore, isulin dose can be reduced.

Moreover, based on improved internal environment achieved by Micro-Chinese Medicine Osmotherapy, Stem Cell Transplant can repair damaged glomerular epithelial cells, improve the reabsorption of protein by renal tubules. That's why 24-hour urinary protein decreases by 2.75 g in this case.

In conclusion, through many clincal applications, the combination of Micro-Chinese Medicine Osmotherapy and Stem Cell Transplant has been proved to be a safe way of improving islet and kidney fucntions.

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