Micro-Chinese Medicine Osmotherapy and Stem Cell Transplant for Diabetic Nephropathy (Diabetic Kidney Disease)

Profile

Name: Nitin

Age: 63

Gender: Male

Country: India

Diagnosis: Diabetic Kidney Disease (Diabetic Nephropathy)

Treatment: Micro-Chinese Medicine and Osmotherapy, twice Mesenchymal Stem Cells (MSC)

Background

Nitin is a 63 year old male patient from India. He was admitted at Shijiazhuang Kidney Disease Hospital for Micro-Chinese Medicine Osmotherapy and Stem Cell Transplantation (Mesenchymal Stem Cells) of his Diabetic Kidney Disease (Diabetic Nephropathy).

Fifteen years ago, he was found to have a high blood sugar when he took an examination.

Fasting blood-glucose (FBG): 7.0mmol/L

2-hour postprandial blood-glucose (2hPBG) :14.0mmol/L

Urinalysis

Urine sugar: 3+

Proteinuria (Protein in urine): 2+

He took medicines of glibenclamide and melbinum, but the blood sugar was still not under control. The blood sugar value was in 2.9mmol/L-14.0mmol/L, and he adjusted the medicines because of the fluctuations of blood sugar.

Ten years ago, he began to have light swelling in his lower limbs and backache. Then he sought medical in his local hospital.

The examination showed:

GFR :31.6ml/min

LGFR: 30.3ml/min

Urinalysis

Urine sugar :+-

Proteinuria (protein in urine): 2+

Blood Sugar: 7.21mmol/L

Kidney Function

Serum Creatinine :121.14umol/L

He took oral medicines and almost brought the blood sugar in control.

Fasting blood-glucose (FBG): 6mmol/L-8mmol/L

Postprandial blood-glucose (PBG) :8mmol/L-10mmol/L

When the swelling became light, he reduced the dose of medicines.

Eight years ago, the blood sugar reached up to 18mmol/L and then he stopped taking oral medicines and continued to inject the common insulin. It is injected 50U per day in three times through subcutaneous injection. The blood sugar was the in the normal value but the serum creatinine reached up to 182mmol/L, the proteinuria was fluctuating in 1+ and 3+.

Two years ago, he began to have precordial distress and then he went to his local hospital to receive treatment. Following are the examination results at that time.

Blood sugar: 6.15mmol/L

Serum Creatinine :118umol/L

Uric Acid: 517 umol/L

Echocardiography showed:

Aortosclerosis

Left ventricular contractile function is normal

Decline in left ventricular diastolic function

Coronary angiography showed:

Coronary atherosclerotic heart disease

Three-vessel coronary disease

24 hours dynamic electrocardiographic monitor shows

Sinus bradycardia

Occasional atrial premature beats

It was diagnosed as Coronary Atherosclerotic Heart Disease, Sinus Arrhythmia, Type 2 Diabetes, Diabetic Kidney Disease (Diabetic Nephropathy) and High Blood Pressure Level 3. He was give treatment of lowering blood glucose, blood pressure, anti-coagulation, anti-inflammatory and intracoronary stent implantation. The symptoms are relieved.

One year ago, he took an examination because of his blurred vision, which showed Diabetic Retinopathy.

Sonography showed

Left Renal Cyst (2.5*2.5cm)

Both Kidneys Shrink (left kidney 9.5*4.0cm, right kidney 9.3*4.4cm)

Then he was given medicine to deal with these symptoms and the condition turned better.

However, half a year ago, the blood sugar was out of control. He went to his local hospital again.

Fasting C-peptide: 1.06NG/L

60 minutes Postprandial C-peptide: 1.54NG/L

120 minutes Postprandial C-peptide: 11.23NG/L

180 minutes Postprandial C-peptide: 8.52NG/L

Fasting Blood Sugar: 3.6mmol/L

60 minutes Postprandial Blood Sugar: 11.7mmol/L

120 minutes Postprandial Blood Sugar: 10.8mmol/L

He was injected with insulin for 45U everyday, and the blood sugar was almost under control. To get rid of his disease, he then went to our hospital for treatment. He had the symptoms of frequent urination, urgent urination and excessive urine at night, but did not have the symptoms of pain when urination and hematuria (blood in urine).

Past Medical History

He has had high blood pressure for 40 years and he took medicines of Felodipine Sustaind Release Tablets and Betaloc to control it. The blood pressure was in 120-140/90mmhg. He has two brothers who have Diabetes and Coronary Disease.

Physical Examination

T: 36.7℃

P: 60 times per minute

R: 20 times per minute

BP: 150/90mmhg.

There was no anemia appearance and no swelling in eyelid. The cardiac enlarged, and the heart rate was 60 times per minute. There were moderate swelling in his lower limbes.

Auxiliary Examination

Kidney Function: CREA 118umol/L URIC:474umol/L

Fasting blood sugar: 5.49mmol/L

Urinalysis: Pro 1+ 24hours Urine Routine 3.98g/24h

The diagnosis after hospitalization

Type 2 Diabetes, Diabetic Kidney Disease stage Ⅴ, Diabetic Peripheral Neuropathy, Diabetic Retinopathy I, High Blood Pressure stage 2 ( Very High Risk)

Treatment Process

He was given treatment of Micro-Chinese Medicines One and Micro-Chinese Medicines Five after hospitalization for twice per day. He also took the following drugs as an auxiliary:

Mycelium 30ml, three times per day

Insulin Aspart(NovoRapid)base 20U: 8U in the morning, 7U at noon and 7U at night

Losartan Potassium tablets

Ten days later, micro-Chinese Medicines are changed into double 5. He received Mesenchymal Stem Cells (MSC) 2 weeks later after hospitalization. And he continued receiving double 5 Micro-Chinese Medicines with energy mixture. A week later, he left hospital and the indexes are as follows

Serum creatinineFasting blood glucose 24 hours proteinuriaInsulin dosage Blood pressure Neurological symptoms

Before treatment118μmol /L8.46 mmol/L3.98 g/24h45150/90mmH Yes

After treatment102μmol /L6.2 mmol/L3.22 g/24h43140/90mmH No

Discussion

The micro-Chinese Medicine Osmotherapy have the functions of dilating blood vessels and anti-coagulation etc., which can provide a good inner environment for the perfusion of Stem Cells. What is more, it has the functions of changing the state of ischemia and anemia caused by epithelial cells damage, blocking the progression of renal fibrosis from root. The Stem cells can repair the Pancreatic βcells and produce the new ones. When they are back to work and secrete more insulin, the blood sugar can be brought down. The stem cells can also repair the kidney intrinsic cells and rebuild the immune system, thus avoiding the damage of pancreatic cells again.

So, Micro-Chinese Medicine Osmotherapy and Stem Cell Transplantation provides a promising future for the treatment of Diabetic Kidney Disease.

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