The Newest Treatment Methods of Diabetic Nephropathy in Shijiazhuang Kidney Disease Hospital
After diagnosis, patients should start treatment as soon as possible. The conventional treatments are listed as follow:
1. Controlling high blood glucose strictly
Once Diabetic Nephropathy is confirmed, it is best to use insulin to control high blood glucose. The standard is: 1,FBG is below 6.0mmol/L, 2-h PG is below 7.8mmol/L, and HbA1c is below 7%.
2. Controlling blood pressure and reduce urine protein
The medications most used are ACEI or ARB and aldosterone receptor antagonist, but the patients are at higher risk of getting hyperkalemia.
When the urine protein is below 1.0g/24h, blood pressure should be 130/80mmHg, but when the urine protein is above 1.0g/24h, the blood pressure should be limited to 125/75mmHg.
3. Adjusting blood-fat
The standard is that total cholesterol should be below 4.5mmol/L, LDL(low-density lipoprotein) is below 1.5mmol/L, HDL(high-density lipoprotein) is above 1.1mmol/L, and the triglyceride is below 1.5mmol/L.
4. Low-protein diet
It is recommended that patients at the early stage of Diabetic Nephropathy should limit the intake of protein, whose standard is 0.5-0.8gram per kilogram. The reason is that numerous studies have confirmed that high-protein diet can aggravate the conditions of the kidney.
5. Dialysis and kidney transplant
For patients at the medium and end stage of Diabetic Nephropathy, dialysis and kidney transplant are two options. But since kidney donors are scarce and the expenses are incredibly high, most patients have to rely on dialysis to extend their lives. And with the development of the dialysis techniques, patients now enjoy a longer and better life than before.
However, both dialysis and kidney transplant brings many unpredictable consequences. During the dialysis treatment, kidney patients tend to develop many complications. As for kidney transplant, patients would experience great physical pain and take anti-rejection drugs for a long time, and the transplanted kidneys have a high rate of shrinking and failing, according to statistics.
But in Shijiazhuang Kidney Disease Hospital, China, we use Micro-Chinese Osmotherapy and stem cell transplant to treat Diabetic Nephropathy, which has achieved satisfying treatment results for both Chinese patients and international patients. Below is the introduction of the two distinctive treatment methods in our hospital.
Ⅰ. Micro-Chinese Medicine Osmotherapy treatment
1. Micro-Chinese Medicine Osmotherapy can lower the high internal glomerular pressure and improve the abnormal glomerular hemodynamics through the following functions:
After the Micro-Chinese Medicine goes into the human body, first it can activate the functions of the endothelial cells in the glomerular capillary, which has been damaged by hyperglycemia.
Secondly, it can activate the mesangial cell(MC) damaged by hyperglycemia, oppress its reproduction and morphological transformation caused by inflammatory reaction, limit its synthetization and secretion of ECM(extracellular matrix). On the other hand, the Micro-Chinese Medicine can promote mesangial cells to secrete MMPS(matrix etalloproteinases), enhance the degradation of the ECM, which could stave off the fibrosis of the glomeruli.
Thirdly, the active substances in Micro-Chinese Medicine can block the shrinking of mesangial cells, further improving the effective perfusion of glumeruli. At the same time, it can boost the permeability of glomerular filtration barrier, reduce the quantity of urine protein and delay the decline of the patients’ kidney function.
2. Micro-Chinese Medicine can also oppress the effects produced by hyperglycemia
Micro-Chinese Medicine can expand the blood vessels, change the structure and synthetization of the endothelial cells and mesangial cells, which have been damaged by hyperglycemia. It can also boost the function of the cells and extend their lives. What’s more, the Micro-Chinese Medicine can promote the antioxidant function of the SOD(Super oxide Dismutase), glutathione and peroxidase, which can restrain the toxicity of hyperglycemia.
Ⅱ. Stem cell transplant treatment
What is stem cell?
Stem cell is a type of cell that has not differentiated sufficiently and is not mature enough. According to the developmental stages it is, the stem cell can be divided into embryonic cell and somatic cell. But based on the growth potential it possess, it can be divided into three types: totipotent stem cell, pluripotent stem cell and unipotent stem cell.
Stem cells possess the self-renewing ability which means stem cells can regenerate mass of offsprings that may have the same characteristics as the original stem cells. In addition, stem cells also have the potential of differentiating into functional cells to form new tissues and organs. It is called the “omnipotent cell” in the medical community.
What is stem cell transplant treatment?
Stem cell transplant is an operation where the stem cells are extracted from different organs of human body, then after cultivation and differentiation, the stem cells are transplanted into patients; body to repair the damaged tissues and organs using the self-reproduction and differentiation ability of stem cells.
After stem cells are transfused into the human body, the stem cell would go to the damaged parts in kidney and pancreas, differentiating into the various cells needed, repairing and replacing the intrinsic cells of kidney and pancreas.
For kidney function, stem cell can help kidney regain its function, block and reverse the fibrosis process of kidney. Fibrosis process is the culprit that results in kidney failure.
For pancreas function, stem cells can differentiate into newβcells that would replace the already dead cells, adjusting the immune mechanism of the whole body and promoting the pancreas regain its function.
In Shijiazhuang Kidney Disease Hospital, stem cells are used to treat different forms of kidney diseases, including Diabetic Nephropathy.
Ⅲ. The combination of Micro-Chinese Medicine Osmotherapy and Stem Cell Transplant in Shijiazhuang Kidney Disease Hospital
Both Micro-Chinese Medicine Osmotherapy and stem cell transplant are used together to treat Diabetic Nephropathy.
On one hand, stem cells can directly repair and replace the damaged kidney cells and the βcells in pancreas; on the other hand, the active substances in Micro-Chinese Medicine could reach the lesions, repairing the damaged cells. What’s more, it can create a favourable environment for the growth of stem cells by the functions such as expansion of blood cells, anti-inflamation and degradation.
Here is the result of our combined treatment in Shijiazhuang Kidney Disease Hospital ：
In the short term, the MAU(microalbuminuria),occult blood and blood glucose would be lower. In the long term, the pancreas function and kidney cells are both repaired, the dose of insulin and antidiabetic drugs would be reduced,or even abandoned in many cases.
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