Anemia, a Sign of Uremia(Kidney Failure)
In general, anemia can happen in the medium and late stage of CKD(chronic kidney disease), that is, when the serum creatinine is above 166.8 140μmoI/L. However, many patients would regard their anemia as iron-deficiency anemia, since they do not have medical history of kidney disease, and they have never done urine tests. Actually, renal anemia is a common phenomenon, which unfortunately is not known to many people.
Human body produces five hundred million new red blood cells each hour, which is integrated by EPO (erythropoietin) and iron ion. EPO is, in fact, a hormone, and is in charge of the production of red blood cells.
Most of the EPO is secreted by kidney. When the EPO goes into the bloodstream, it would promote the production of red blood cell in the bone marrow, increasing its quantity in the bloodstream. In the bloodstream, the EPO should be kept in certain amount, so that human beings would have normal metabolism of red blood cells. When the kidney has been damaged to certain degree, the kidney’s ability of producing EPO would decrease, resulting in anemia.
Lack of EPO is not the only factor that could lead to anemia; but once renal anema happens, it could affect all the organs in the body and result in many complications. It would cause heart enlargement and cardiac hypertrophy, increasing the rate of cardiovascular events. It would also speed the deterioration of kidney, triggers cognitive dysfunction, irregular period, declining sexual ability and immune system.
In light of what has been said, patients should check their kidney condition once serious anemia in spotted. And if renal anemia is confirmed, patients should adopt treatment immediately.
Treatment of anemia is a comprehensive one, since the reasons that causes anemia can be many. Here are the main treatment methods:
1. give patients sufficient amount of recombinant human erythropoietin (rHuEPO). Recombinant human erythropoietin (rHuEPO) is a milestone in treating renal anemia, and is also the major treatment method. But use of recombinant human erythropoietin should be guided by specialists, and adjust the dose based on the patients’ conditions.
2. supplement iron and other substances that can needed to produce red blood cell
3. treat factors that are aggravating anemia, such as haemorrhage, malnutrition, infection and hyperparathyroidism.
If you still have questions , feel free to contact our online experts who are ready to give you advice on your treatment based on your specific conditions.