How Can Diabetes Cause Kidney Disease?
High blood sugar level will cause damages to blood vessels, especially to blood capillaries. Kidneys are made of 1 million glomeruli which are constituted with massive blood capillaries, and Diabetes can lead to kidney diseases by the followings:
1. High blood sugar damages glomerular blood capillaries, and the signal of damage enhances blood vessel expansion. So, there will be more blood inflow to kidneys. And the result is inter pressure increase within glomerulus. High pressure further aggravates damages to blood capillaries.
2. Long term high blood sugar level and high blood pressure, make the blood capillaries more penetrable, which means more macro-molecular substances and filter through capillary wall to mesenchymal area, and the accumulation of these macro-substances in mesenchymal area can easily lead to damages.
3. When damages occur to glomerulus, there will be more cell proliferation. Glomerular basement membranes become thick, which blocks the filtration of blood, so there will be more creatinine and other metabolic waste retention within blood.
At the very early stages of Diabetes, damages to kidneys mainly occur to glomerular blood capillaries. And kidneys are in state of high perfusion. There will be enlargement of kidney size.
With the development of Diabetes, damages to renal tubules are involved.
When Microalbumin occurs, that means the kidney disease develops into the third stage. At this time, if the patients can take some proper measures, the kidney damage can be reversed.
In the late stage of Diabetes, protein and creatinine will increase.
So the patients should grasp the best treatment time so the disease can be reversed or controlled. Don’t think Diabetes will always stay as Diabetes. Do take active treatments to keep the kidney disease under control.
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