Renal Injury Manifestation of Patients with Diabetes

1. Proteinuria: at the beginning, because of glomerulus filtration pressure increasing and charge of filtration membrane changing, there is only microalbumin in the urine, and it is selective proteinuria, no globulin increasing, and this kind of condition can last for many years. With increasing of glomerular basilar membrane filtration pore, macro-molecular substances can get through thus non-selective clinical proteinuria showing up. With the development of lesion, proteinuria begins to change into sustained severe proteinuria. If volume of proteinuria is more than 3grams per day, it is symptom of poor prognosis. Proteinuria severity of Patients with Diabetic Nephropathy is progressive development, until Nephritic Syndrome appears.

2. Edema: Patients with Diabetic Nephropathy in early stage generally have no edema. Few patients may have slight edema before plasma protein reducing. When volume of proteinuria in 24 hours is more than 3grams, edema will show up. Obvious edema of the whole body could only be seen in the patients whose Diabetic Nephropathy disease is developing rapidly.

3. High blood pressure: high blood pressure is very common among the patients with Diabetic Nephropathy. Serious kidney disease could cause high blood pressure, and high blood pressure can speed up aggravating of Diabetic Nephropathy. So it is very important to control high blood pressure.

4. Renal insufficiency: once Diabetic Nephropathy begins, its course is progressive. Azotemia and uremia is the final result.

5. Anemia: Diabetics with obvious azotemia might have slight or moderate anemia, treating with chalybeate is invalid.

6. Other symptoms: Diabetic Retinopathy is not the symptom of kidney disease, but it is often accompanied by Diabetic Nephropathy. Some people even thought that, without Diabetic Retinopathy, there won’t be Diabetic Nephropathy.

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