Cord Blood Stem Cells to Treat Type 1 Diabetes
Cord blood is the blood that remains in the newborn's blood after birth. Collecting cord blood cells is a simple, safe, painless procedure that usually takes less than five minutes and happens immediately after birth. After the umbilical blood has been cut, the remaining blood in the cord is collected. Then cord blood is shipped to laboratory; with processes of separation, division and proliferation, the well cultured cord blood stem cells is clinically adopted with venous infusion. Compared with other stem cells, cord blood stem cells have its unique advantages and characteristics:
1. Cord blood cells are not embryonic stem cells and are not controversial.
2. Compared with other stem cells, cord blood cells are biologically younger and more primordial so that they have stronger self-renewing, proliferation and differentiation potentials.
3. The lymphocytes in cord blood has not received the stimulation of foreign antigens yet so that they carry low immunogenicity.
3. They are immediately available, and early treatment can minimize disease progression.
How is cord blood stem cells applied in medical field?
As Cord blood stem cells have been successfully used clinically for more than 20 years to treat many life-threatening diseases including leukemia, blood disorders, many blood diseases and immune-related diseases. It is inspiringly used in cerebral palsy, brain injury, Juvenile Diabetes, myasthenia and so on.
How to treat Type 1 Diabetes with cord blood stem cells?
Type 1 Diabetes(D1DM), an autoimmune disease, is characterized by selective demolition of islet cells and complete shortage of islet secretion. Commonly, Type 1 Diabetes sufferers need to take longstanding exogenous insulin, which can just prolong the development of complications but can not cure the disease. Strong proliferation and division abilities of cord blood stem cells induce targeted-differentiation into islet cells so as to perform its functions of treating Diabetes.
More exactly, cord blood stem cells can repair damaged islet-cells so as to improve insulin secretion and regenerate new islet cells so as to replace necrotic cells. With this process, insulin can be secreted more so that the problem that insulin is not enough for body to regulate high blood glucose. By doing this, blood glucose can be decreased on its own.
With homing abilities, cord blood stem cells can directly enter kidney lesions, repair damaged renal intrinsic cells, regenerate new kidney units to replace the necrotic ones.
High blood glucose, damages islet cells and renal intrinsic cells can be improved so that Diabetes can be well treated by cord blood stem cells.